I have a 2005 2500HD Extended Cab Short Box 8.1L/Allison combo, 3.73 gears 285/75/16 Nitto tires ...
It pulls my 16' enclosed with two sleds in it without even breaking a sweat, and I get EXACTLY the same gas miledge (9-10mpg) towing that trailer @ 65 mph as I did with my old 1/2 ton 5.3L towing the exact same trailer.
I get 9-10 mpg towing my dad's 24' enclosed trailer too ....
It pulls very well, it's quiet, you never have to worry about it not starting when it's 40 below .... BUT...
The gas miledge on them is really bad. Those things were built to tow, and that's it ... I get about 14 unloaded down the highway @ 75 mph ...
15 mph @ 65.
I have a feeling if I'd dump the 285 tires and go back to the stock 245/75/16 tires i'd get better miledge, but those tires just look lame ...
Overall I've been completley happy with the motor .... only thing I wish was different is that it came from the factory with a 44 gallon gas tank.
I am probably gonna put a 30 gallon TransferFlow tank/toolbox combo in here soon so I can get ~450 miles out of a single fillup. As of now I get ~230 or so. (towing)