it's possible
well if it's on a trailer getting pulled down the road idling, im sure he could pull in the 20's with a V10.
they do good, except, the one i had and my neighbors blew up, mine was around 180k, no idea what milege his was at, but it was a year later roughly. those were dodges though, 2 of the guys i work with have the ford V10's and seem to be holding up excellent. they average around 11.5, with a fairly heavy foot.
i have an 8.1L v8 though, and i average around 13 to 14 being very nice, but usually it's 12.5 to 13.4 average empty and 8 to 10 depending how heavy the gooseneck is loaded. but a BB V8 or a V10 are going to get crummy MPG's. now my diesel get way better, but the power and actually not too bad fuel milege of the big gassers for the price is very nice.