I've done alot of research on this load. In my opinion, and as Nate talked about before, there is a lot of powder in that case... maybe even too much. So I am going to go with the .338 utlra. Its comparable to the Weatherby .338-378, except youre looking at $75 for 20 Weatherby cases, versues $45 for 50 RUM cases. Powder is the same between each, bullets are the same, ect. Plus youre looking at $830 for a Rem 700 XCR with a 26" barrel, or $1500 for a base Weatherby. The big defference between the .30 cal and the .338 is bullet weight. When you get down past 500yds the heavier grain (for example 225 or 250) is going to be packing alot more energy than the commomn 180 gr. out of the .300 cal. The best performing powder Ive read about is the Alliant 25, I have used this in my 7mm Mag with great success. (Problem there is I can only get a 175gr bullet in 7mm). Its a slower burning powder that produces greater compression.
The biggest thing over-looked is the optics, it doesnt matter if your gun can shoot +1000yds if you cant see your target youre going to miss.