Have an '08 F-350 and the mileage estimates above are spot on. I get about 10mpg pulling a 29' enclosed trailer. V-10's definately love RPM's. Have had 3 diesels prior to the V-10 and could still kick myself for selling the '05 Duramax. However as much as I tow now a days (3 to 4 trips a year) the V-10 does fine and was 7 grand cheaper than the 6.4 liter that doesn't get any better fuel economy. Overall pretty happy with truck and V-10.