I've got 50,000kms on my 2010 2500. Been running Mini Maxx/trans software, deletes etc for 10,000kms. The truck runs so much better. Throttle response, fuel economy, and power are awesome. But be warned, the auto 68Rfe will not hold up to the hot tunes. It's fine in the first few gears but the converter starts shuddering pretty bad if you load up the power in 5th or 6th. If you enjoy your stock tranny, don't tow hard on anything above the Mild tune.
I run Mild full time as a daily driver and towing. No issues. I have my boost limited at 30psi until I can install head studs. Sometime down the road, I will get a transmission built and be able to run the full power tunes WOT in any gear. I will be keeping this truck until she's old and rusty, love this thing.