I would bet most people with Turbo sleds do not run them with high boost most of the time.
We run ours mostly around 12lbs and its plenty to get you into trouble. Our's are both 4strokes. One Nytro and one Apex. I come from Skidoo's. I also just bought a Skidoo for a third sled. Small 600 though.
I have almost 2900 miles on my boosted Apex, and have loved it almost the entire time. Three oil changes, three belts, two sets of hyfaxes, and a sh!t eaten grin is what I have to show for it. The only times I do not like it are when the snow is just set up enough to make pulling it over a chore. If the snow is setup hard its fine, and if its deep its great, but the in between can be a workout. The Nytro is much better in that aspect.
Depending on the kind of riding you prefer, one would be better than the other in my opinion. If you like to do everthing, you will love the 4stroke Turbo. If you prefer the tight trees, creek bottoms and such, a smaller sled would suit you better.
For my kind of riding, I dont have any plans to ever return to a non turbo sled. No matter 2 or 4 stroke, it will have a turbo. The advantage to the 4 stroke right now would be lesser quality fuel for the amount of boost, reliability, cost to up keep(belts, oil, etc.). The down side is weight.
If I did not put on as many miles as I do in a year, the cost of fuel and upkeep would not matter as much to me.
Good luck with your choice.