I haven't tried switching my new-to-me Pro to ethanol mode, but if it's like my old EDGE in regular gas mode, it kills so much power you'd think something was wrong with it. I'm fortunate, I can get ethanol-free from several stations near me, and that's best if at all possible. That said, I know in some states it's easier to find heroin than pure premium. I'd think there's a reason beyond just octane that Poo only specifies non-eth mode for pure premium, but can't think of a reason why fuel conditioner and/or octane booster wouldn't give you enough margin to keep you safe.
Can't say what products would do the most good; I've run Lucas ethanol stabilizer in my cars when I can't get eth-free, but that's been more of a feel-good thing than something I know makes a difference. Ethanol does kill though: I've had to replace both fuel pumps, the fuel pressure regulator, and rebuild the fuel distributor on my Mercedes in the last few years. They'd been replaced before, but the steady diet of California gas before I got it took its toll. If you do have to run ethanol, definitely run something to boost the octane a few points (20-30% avgas is probably better than additives) and always run it on fresh fuel. Not sure how sensitive the det sensor is, but I'd also keep an eye on the plugs for flecks of aluminum just in case you're getting a light knock the det sensor isn't picking up.